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Updated 11/10/2012



Heart Attack | Myocardial Infarction Studies

The studies below discuss heart attack or Myocardial Infarction (MI) studies.
updated 1/26/2013 Author Interview: Karen Wildi, MD

Uric acid for diagnosis and risk-stratification in suspected myocardial infarction
Wildi K, Haaf P, Reichlin T, Acemoglu R, Schneider J, Balmelli C, Drexler B, Twerenbold R, Mosimann T, Reiter M, Mueller M, Ernst S, Ballarino P, Zellweger C, Moehring B, Vilaplana C,
Freidank H, Mueller C.
Department of Cardiology, University Hospital, Basel, Switzerland
Eur J Clin Invest. 2013 Feb;43(2):174-82. doi: 10.1111/eci.12029. Epub 2012 Dec 21. Author Interview: Mia Nielsen, MB

Familial clustering of myocardial infarction in first-degree relatives: a nationwide study

Mia Nielsen, Charlotte Andersson, Thomas A. Gerds, Per Kragh Andersen, Thomas Bo Jensen, Lars Køber,
Gunnar Gislason, and Christian Torp-Pedersen

Eur Heart J first published online January 7, 2013 doi:10.1093/eurheartj/ehs475

Matthew E. Dupre, PhD, assistant professor of medicine, Duke University, Durham, N.C 

The Cumulative Effect of Unemployment on Risks for Acute Myocardial Infarction

Dupre ME, George LK, Liu G, Peterson ED. The Cumulative Effect of Unemployment on Risks for Acute Myocardial Infarction.
Arch Intern Med. 2012;():1-7. doi:10.1001/2013.jamainternmed.447. Author Interview: Dr Andrew Wragg, Consultant Cardiologist at BMI Healthcare.

Safety and feasibility of hospital discharge 2 days following primary percutaneous intervention for ST-segment elevation myocardial infarction.

Jones DA, Rathod KS, Howard JP, Gallagher S, Antoniou S, De Palma R, Guttmann O, Cliffe S, Colley J, Butler J, Ferguson E, Mohiddin S, Kapur A, Knight CJ, Jain AK, Rothman MT, Mathur A, Timmis AD, Smith EJ, Wragg A.

Heart. 2012 Oct 10. [Epub ahead of print] Author Interview: Francisco Costa, MD

Impact of ESC/ACCF/AHA/WHF universal definition of myocardial infarction on mortality at 10 years

Francisco Moscoso Costa, Jorge Ferreira, Carlos Aguiar, Hélder Dores, João Figueira, and Miguel Mendes
Impact of ESC/ACCF/AHA/WHF universal definition of myocardial infarction on mortality at 10 years Eur Heart J first published online September 17, 2012 doi:10.1093/eurheartj/ehs311 Author Interview

Number of Coronary Heart Disease Risk Factors and Mortality in Patients With First Myocardial Infarction

Canto JG, Kiefe CI, Rogers WJ, Peterson ED, Frederick PD, French WJ, Gibson CM, Pollack CV, Ornato JP, Zalenski RJ, Penney J, Tiefenbrunn AJ, Greenland P.  Number of Coronary Heart Disease Risk Factors and Mortality in Patients With First Myocardial Infarction. JAMA 2011;306:2120-2127 Author Interview: Professor Dr. Christian Müller

One-Hour Rule-out and Rule-in of Acute Myocardial Infarction Using High-Sensitivity Cardiac Troponin T.

Reichlin T, Schindler C, Drexler B, Twerenbold R, Reiter M, Zellweger C, Moehring B, Ziller R, Hoeller R, Rubini Gimenez M, Haaf P, Potocki M, Wildi K, Balmelli C, Freese M, Stelzig C, Freidank H, Osswald S, Mueller C.

Arch Intern Med. 2012 Aug 13:1-8. doi: 10.1001/archinternmed.2012.3698. [Epub ahead of print] Author Interview:   Myung-Ho Jeong, MD, PhD

Benefit of Percutaneous Coronary Intervention in Early Latecomers With Acute ST-Segment Elevation Myocardial Infarction.

Sim DS, Jeong MH, Ahn Y, Kim YJ, Chae SC, Hong TJ, Seong IW, Chae JK, Kim CJ, Cho MC, Rha SW, Bae JH, Seung KB, Park SJ; Other Korea Acute Myocardial Infarction Registry (KAMIR) Investigators.
Chonnam National University Hospital, Gwangju, Republic of Korea.
Am J Cardiol. 2012 Jul 21. [Epub ahead of print] Author Interview: Arief Lalmohamed, PharmD

Timing of Acute Myocardial Infarction in Patients Undergoing Total Hip or Knee Replacement:
A Nationwide Cohort Study

Lalmohamed A, Vestergaard P, Klop C,  et al.  Timing of acute myocardial infarction in patients undergoing total hip or knee replacement: a nationwide cohort study [published online July 23, 2012].  Arch Intern Med

Author Interview:Paddy Barrett MD MRCPI
Characterization of Circulating Endothelial Cells in Acute Myocardial Infarction

Samir Damani, Andrea Bacconi, Ondrej Libiger, Aparajita H. Chourasia, Rod Serry, Raghava Gollapudi,RonGoldberg, Kevin Rapeport, Sharon Haaser, Sarah Topol, Sharen Knowlton, Kelly Bethel,Peter Kuhn, Malcolm Wood, Bridget Carragher, Nicholas J. Schork, John Jiang, Chandra Rao,Mark Connelly, Velia M. Fowler, and Eric J. Topol

Sci Transl Med 21 March 2012 4:126ra33. [DOI:10.1126/scitranslmed.3003451]

Treating heart attack with fat-derived stem cells may be safe in humans
American Heart Association Meeting Report - Abstract 12225/P6021

Study Highlights:

  • Treating heart attack patients with regenerative stem cells obtained from their own fat deposits may be feasible and safe, according to a small, first-of-its-kind study.

  • Heart muscle damage in stem cell-treated patients decreased more than half after six months; placebo-treated patients showed no change.

  • Stem cell recipients had a greater increase in heart function, but the difference was not considered significant.

Author Interview: Giuseppe Berton, MD,FESC

Predictors of Ten-Year Event-Free Survival in Patients With Acute Myocardial Infarction (from the Adria, Bassano, Conegliano, and Padova Hospitals [ABC] Study on Myocardial Infarction).

Berton G, Cordiano R, Cavuto F, Giacomini G, De Toni R, Palatini P.

Department of Cardiology, Conegliano General Hospital, Conegliano, Italy.
Am J Cardiol. 2012 Jan 3. [Epub ahead of print]

Author Interview: Eugenia Nikolsky, MD, PhD

Myocardial Infarction (from the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction [HORIZONS-AMI] Trial).

Nikolsky E, Mehran R, Dangas GD, Yu J, Parise H, Xu K, Pocock SJ, Stone GW.
Rambam Health Care Campus and Technion Israel Institute of Technology, Haifa, Israel; Cardiovascular Research Foundation, New York, New York.
Am J Cardiol. 2011 Dec 21. [Epub ahead of print]

Author Interview: Claes Held MD

Physical activity levels, ownership of goods promoting sedentary behaviour and risk of myocardial infarction: results of the INTERHEART study

Eur Heart J first published online January 11, 2012 doi:10.1093/eurheartj/ehr432
2012 doi:10.1093/eurheartj/ehr432
Claes Held, Romaina Iqbal, Scott A. Lear, Annika Rosengren, Shofiqul Islam,James Mathew, and Salim Yusuf

Author Interview: A.M. van der Laan, MD

A proinflammatory monocyte response is associated with myocardial injury and impaired functional outcome in patients with ST-segment elevation myocardial infarction: Monocytes and myocardial infarction

Anja M. van der Laan, Alexander Hirsch, Lourens F.H.J. Robbers, Robin Nijveldt, Ingrid Lommerse, Ronak Delewi, Pieter A. van der Vleuten, Bart J. Biemond, Jaap Jan Zwaginga, Wim J. van der Giessen, Felix Zijlstra, Albert C. van Rossum, Carlijn Voermans, C. Ellen van der Schoot, Jan J. Piek 

American Heart Journal - January 2012 (Vol. 163, Issue 1, Pages 57-65.e2,
DOI: 10.1016/j.ahj.2011.09.002)

Author Interview: Deborah A. Levine, MD, MPH
Improving Care After Myocardial Infarction Using a 2-Year Internet-Delivered Intervention
The Department of Veterans Affairs Myocardial Infarction–Plus Cluster-Randomized Trial

Deborah A. Levine, MD, MPH; Ellen M. Funkhouser, DrPH; Thomas K. Houston, MD, MPH; Joe K. Gerald, MD, PhD; Nancy Johnson-Roe, BSN, MPH; Jeroan J. Allison, MD, MSc; Joshua Richman, MD, PhD; Catarina I. Kiefe, PhD, MD
Arch Intern Med. 2011;171(21):1910-1917. doi:10.1001/archinternmed.2011.498

Author Interview: Dr. Antonio Abbate, MD

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

Eleonora Mezzaroma, Stefano Toldo, Daniela Farkas, Ignacio M. Seropian,
Benjamin W. Van Tassell, Fadi N. Salloum, Harsha R. Kannan, Angela C. Menna, Norbert F. Voelkel, and Antonio Abbate

PNAS 2011 ; published ahead of print November 21, 2011, doi:10.1073/pnas.1108586108

Author Interview: Dr. Richard Body
Rapid Exclusion of Acute Myocardial Infarction in Patients With Undetectable Troponin Using a High-Sensitivity Assay

Body, Richard, Carley, Simon, McDowell, Garry, Jaffe, Allan S., France, Michael, Cruickshank, Kennedy, Wibberley, Christopher, Nuttall, Michelle, Mackway-Jones, Kevin
J Am Coll Cardiol 2011 58: 1332-1339

Author Interview: Patrick Lawler, MD

Efficacy of exercise-based cardiac rehabilitation post–myocardial infarction: A systematic review and meta-analysis of randomized controlled trials

Efficacy of exercise-based cardiac rehabilitation post–myocardial infarction: A systematic review and meta-analysis of randomized controlled trials Patrick R. Lawler, Kristian B. Filion, Mark J. Eisenberg
American Heart Journal - 05 September 2011 (10.1016/j.ahj.2011.07.017)

Author Interview: Dr. Adam Salisbury, MD

Diagnostic Blood Loss From Phlebotomy and Hospital-Acquired Anemia During Acute Myocardial Infarction

Salisbury AC, Reid KJ, Alexander KP, Masoudi FA, Lai SM, Chan PS, Bach RG, Wang TY, Spertus JA, Kosiborod M.
Arch Intern Med. 2011 Aug 8.

Author Interview: Adam C. Salisbury, MD, MSc

Recovery From Hospital-Acquired Anemia After Acute Myocardial Infarction and Effect on Outcomes.

Salisbury AC, Kosiborod M, Amin AP, Reid KJ, Alexander KP,
Spertus JA, Masoudi FA.
Saint Luke's Mid America Heart Institute, Kansas City, Missouri; University of Missouri-Kansas City School of Medicine, Kansas City, Missouri.
Am J Cardiol. 2011 Jul 22

Author Interview: Renato Delascio Lopes, MD, PhD, MHS

Diagnosing Acute Myocardial Infarction in Patients With Left Bundle Branch Block.

Lopes RD, Siha H, Fu Y, Mehta RH, Patel MR, Armstrong PW, Granger CB.
Am J Cardiol. 2011 Jul 2.
Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.

Authors' Interview: Drs. Cheol Whan Lee and Seung-Jung Park

Comparison of Differential Expression of P2Y(12) Receptor in Culprit Coronary Plaques in Patients With Acute Myocardial Infarction Versus Stable Angina Pectoris.

Lee CW, Hwang I, Park CS, Lee H, Park DW, Kang SJ, Lee SW, Kim YH, Park SW, Park SJ.
Department of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
Am J Cardiol. 2011 Jul 2

Author Interview: Dr. Anne-Marie Schjerning Olsen
Duration of Treatment With Nonsteroidal Anti-Inflammatory Drugs and Impact on Risk of Death and Recurrent Myocardial Infarction in Patients With Prior Myocardial Infarction

Circulation. 2011
doi: 10.1161/CIRCULATIONAHA.110.004671

JAMA: Administration of Erythropoietin to Patients With Heart Attack Who Undergo Coronary Intervention Procedures Does Not Reduce Size of Heart Muscle Involvement and is Associated With Higher Rates of Adverse Events

CHICAGO—Intravenous administration of epoetin alfa, a product that stimulates red blood cell production, to patients with heart attack who were undergoing percutaneous coronary intervention (PCI; procedures such as balloon angioplasty or stent placement used to open narrowed coronary arteries), did not provide reduction in the size of the heart muscle involved and was associated with higher rates of adverse cardiovascular events, according to a study in the May 11 issue of JAMA

Author Interview: Sripal Bangalore, MD, MHA, FACC, FSCA

Angiotensin receptor blockers and risk of myocardial infarction: meta-analyses and trial sequential analyses of 147 020 patients from randomised trials.

Bangalore S, Kumar S, Wetterslev J, Messerli FH.
BMJ. 2011 Apr 26;342:d2234. doi: 10.1136/bmj.d2234.

Author Interview Adam Salisbury, MD, MSc

Patterns and Predictors of Fast Food Consumption After Acute Myocardial Infarction

Adam C. Salisbury, Paul S. Chan, Kensey L. Gosch, Donna M. Buchanan, John A. Spertus
American Journal of Cardiology - 15 April 2011 (Vol. 107, Issue 8, Pages 1105-1110, DOI: 10.1016/j.amjcard.2010.12.005)

Author Interview: Dr. Ryan Longmore
Angina frequency after myocardial infarction and quality of life in older versus younger adults: The Prospective Registry Evaluating Myocardial Infarction: Event and Recovery study

Longmore RB, Spertus JA, Alexander KP, Gosch K, Reid KJ, Masoudi FA, Krumholz HM, Rich MW.St
Am Heart J. 2011 Mar;161(3):631-8.
Luke's Mid-America Heart Institute, University of Missouri-Kansas City, USA.

Regional prevention project involving 10,000 adults cuts heart attacks by 25 percent

The Heart of New Ulm Project, which is merging environmental, peer leadership and individual interventions across an entire rural Minnesota community with the assistance of a healthcare system, worksites and the general community to prevent coronary heart disease, has shown a 24 percent reduction in the number of acute heart attacks in a five-quarter period, compared with the previous five-quarter period of evaluation.

Smoking, alcohol consumption, physical activity, and family history and the risks of acute myocardial infarction and unstable angina pectoris: a prospective cohort study
Audrey HH Merry, Jolanda MA Boer, Leo J Schouten  Edith JM Feskens  WM Monique Verschuren  Anton PM Gorgels  and Piet A van den Brandt
BMC Cardiovascular Disorders 2011, 11:13doi:10.1186/1471-2261-11-13
Published March 24 2011Abstract (provisional)

Early statin therapy within 48 hours decreased one-year major adverse cardiac events in patients with acute myocardial infarction.

Int Heart J. 2011;52(1):1-6.

Kim MC, Ahn Y, Cho KH, Lee MG, Ko JS, Park KH, Sim DS, Yoon NS, Yoon HJ, Kim KH, Hong YJ, Park HW, Kim JH, Jeong MH, Cho JG, Park JC, Kang JC.
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital.

FDA Drug Safety Podcast for Healthcare Professionals: Safety Review update of Abacavir and possible increased risk of heart attack

(Podcast transcript)
Welcome, my name is Lindsay Davison, a pharmacist in the Division of Drug Information.  On March 1, 2011, the Food and Drug Administration issued a Drug Safety Communication updating the public about its ongoing safety review of abacavir and a possible increased risk of heart attack.  Abacavir is an antiviral medication used in combination with other antiretroviral drugs for the treatment of HIV-1 infection. 

Available medications that contain abacavir include Ziagen, Trizivir, and Epzicom.

When and why do heart attacks occur? Cardiovascular triggers and their potential role.

Hosp Pract (Minneap). 2010 Aug;38(5):144-52.

Schwartz BG, Mayeda GS, Burstein S, Economides C, Kloner RA.
Therapeutic Endoscopy Gastroenterology and Hepatology Huntsman Cancer Center University of Utah, Salt Lake City, UT 84132, USA.

Influenza vaccination, pneumococcal vaccination and risk of acute myocardial infarction: matched case-control study

Siriwardena A, et al
CMAJ 2010; DOI: 10.1503/cmaj.091891.

Incidence of acute myocardial infarction resulting in sudden death outside the hospital.

Emerg Med J. 2010 Sep 8.

Adnet F, Renault R, Jabre P, Kulstad E, Galinski M, Lapostolle F.
SAMU 93 - EA 3409, Avicenne Hospital, Bobigny, France

Clinical and laboratory characteristics in patients with acute myocardial infarction due to occlusive vasospasm.

J Cardiol. 2010 Aug 25.

Kim W, Cho JS, Hong YJ, Ahn Y, Jeong MH.
The Cardiology Division, Department of Internal Medicine, Kyung Hee University, Seoul, Republic of Korea.





Angina | Heart Disease Resourses | Chest Pain Editorial Review:

Philips HeartStart Home Defibrillator (AED)

Be prepared for the unexpected.
When sudden cardiac arrest (SCA) strikes, the electrical system of the heart short circuits, causing the heart to quiver rather than pump in a normal rhythm. It typically results in the abnormal heart rhythm know as ventricular fibrillation (VF). It usually happens without warning and the majority of people have no previously recognized symptoms of heart disease. And it most often happens at home. For the best chance of survival from SCA caused by VF, a defibrillator should be used within 5 minutes. Yet, less than 1 in 20 people survive largely because a defibrillator does not arrive in time.
Just as seat belts or airbags do not save every life in a traffic accident, a defibrillator will not save every person who suffers a sudden cardiac arrest. Yet many lives could be saved if more people could be reached more quickly.



cardiac defibrillator, heart start defibrillator

Philips HeartStart Home Defibrillator (AED)



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