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Erectile Dysfunction | ED | Cardiovascular Disease
Patients with erectile dysfunction (ED) not infrequently have associated cardiovascular risk factors as well as atherosclerosis. This study demonstrated ED to also be associated with a higher risk for cardiovascular events in men with both ED and cardiovascular disease.
Reference:
Erectile Dysfunction Predicts Cardiovascular Events in High-Risk Patients Receiving Telmisartan, Ramipril, or Both. The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial/Telmisartan Randomized Assessment Study in ACE Intolerant subjects with Cardiovascular Disease (ONTARGET/TRANSCEND) Trials
March 15, 2010
Circulation
Featured Angina| Acute Coronary Syndrome and Heart Disease Interviews
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Author Interview: Claes Held MD
Associate professor at Uppsala Clinical Research Center and the
Cardiology department at Uppsala University Hospital in Sweden
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Publication:
Physical activity levels, ownership of goods promoting sedentary behaviour and risk of myocardial infarction: results of the INTERHEART study
Eur Heart J first published online January 11, 2012 doi:10.1093/eurheartj/ehr432
2012 doi:10.1093/eurheartj/ehr432
Claes Held, Romaina Iqbal, Scott A. Lear, Annika Rosengren, Shofiqul Islam,James Mathew, and Salim Yusuf
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What are the main findings of the study?
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The main findings are he following:
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It is well known that physical inactivity is a risk factor for developing cardiovascular disease.
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Our study shows that being physically active reduces the risk of having a heart attack.
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Older studies have mostly studied people in the developed countries. This study which has a global perspective and includes 52 countries from all continents, shows that physical inactivity reduces the risk also in both low- middle-and high-income countries.
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We also found that ownership of a car and TV was associated with a more than doubled risk of being sedentary and that in low- and middle income the risk for a heart attack was increased with 27 %.
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We can however, not conclude from this study that there is a causal relationship but it is an interesting finding.
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Were any of the findings unexpected?
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We looked at the relationship between physical activity both at work and during leisure time.
A bit surprising was that people with heavy physical labor did not have a reduction in the risk of heart attacks, whereas people with both mild and moderate intensity did.
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What should clinicians and patients take away from this study?
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The main findings above and also that physical activity with duration below the recommended 30 minutes/day does seem to prevent from heart attacks as well although not as much as when you do it according to guidelines.
This may be a comfort to those who are completely sedentary and feel that it would be a too big step to move to the 30 minutes/day right away.
All PA does a good job for the heart as compared to not doing anything at all!
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What recommendations do you have for cardiology health care providers as a result of your study?
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It would be interesting to follow up on the ownership of car and TV and do a prospective study to see if the theory holds true.
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Publication:
Short Telomere Length, Myocardial Infarction, Ischemic Heart Disease, and Early Death
- Maren Weischer, Stig E. Bojesen, Richard M. Cawthon, Jacob J. Freiberg,
Anne Tybjærg-Hansen, and Børge G. Nordestgaard
Arterioscler Thromb Vasc Biol. 2011;ATVBAHA.111.237271published online before print December 22 2011, doi:10.1161/ATVBAHA.111.237271 |
What are the main findings of the study?
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One in four Danes have reduced telomere length, that is, increased cellular ageing, and a 25% increased risk of early death and a 50% increased risk of heart attack.
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Were any of the findings unexpected?
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Yes, previous smaller studies have suggested much larger risk increases for early death and heart attack, while we found more modest risk estimates.
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What should clinicians and patients take away from this study?
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A possible prospect of the study is a simple blood test done by the general practitioner, which will reveal a person’s telomeric length and thereby the cellular wear and age.
If the celluar wear is more than expected by age alone, this could be a "wake-up call" suggesting for the patient that now is maybe the time to stop smoking and lose weight.
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What recommendations do you have for cardiology health care providers as a result of your study?
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We need to know if smoking and obesity is the direct cause of reduced telomeric length and thereby increased cellular wear, and whether decreased telomeric length is a direct cause of heart attack and early death.
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